IGF-1 Introduction, history and overview
IGF-1, also known as Somatomedin C, has rapidly become a very popular and much-discussed substance in the mid-2000s to the current year 2017. Rumors have it that its first official use as a performance-enhancing drug was in the early 1990s by that time, Mr. Olympia Dorian Yates, which at the time was considered an extremely rare and expensive medicine, after which the use spread rapidly among other professional bodybuilders.
IGF-1 is none anabolic steroid, but is rather a protein hormone (also known as a polypeptide – or simply a peptide hormone) that is extremely similar to the structure of the insulin hormone – another peptide / protein hormone. IGF-1 is endogenous, naturally produced and is synthesized by the human body primarily in the liver. The production of IGF-1 by the liver is stimulated and activated by Human Growth Hormone (HGH). In essence, HGH is a prohormone for IGF-1, and the majority of the anabolic effects of HGH are actually the result of its downstream production.
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IGF-1 LR3 1 mg
Although this peptide is very similar to insulin (hence the name Insulin-like growth factor 1), its role is somewhat different. Like insulin, IGF-1 is a nutrient shuttling hormone that facilitates the transport of nutrients (such as amino acids and glucose) to muscle cells.
The cells themselves can then use those nutrients to synthesize new muscle tissue. IGF-1 is also anabolic in bone tissue, connective tissue and intestinal tissue. This is different from insulin, which is one nutrient shuttling hormone is in a broader sense of the word because insulin not only transports nutrients to muscle tissue, but also many other tissues throughout the body. In other words, insulin is not as selective as shuttling hormone as IGF-1 is.
Moreover, IGF-1 plays a very unique and very specific number of roles in the human body and its role changes during human development phases. For example, it is responsible for several important factors involved in growth during childhood and also gives anabolic effects in adults.
Medically, its use is primarily for the treatment of growth disorders, but because IGF-1 is a fairly recent discovery in medicine, its experimental use for the treatment of other conditions continues to widen. Medical use and clinical research extends to conditions such as: dwarfism, aging, neuropathy, cancer and even a stroke.
IGF-1 Chemical properties and properties
IGF-1 is a polypeptide hormone that consists of a chain of 70 amino acids in length. For comparison, insulin consists of 51 amino acids in length. As mentioned earlier, it is a nutrient shuttling hormone that is fairly specific to muscle tissue, and it is an extremely anabolic hormone. It is also anabolic for bone tissue, connective tissue and intestinal tissue.
However, a number of very important differences regarding the activity of IGF-1 must be understood: the first is that studies have shown that 99% of IGF-1 circulating in the bloodstream is bound to a number of specific binding proteins, and free (or, unbound) IGF-1 is what is responsible for the proliferation of muscle cells (hyperplasia).
As a result, pharmaceutical research has discovered various methods for modifying the IGF-1 structure to circumvent or avoid this problem of IGF-1 molecules that are bound by binding proteins. The results are, of course, the different variants of IGF-1 that have been developed for use.
The second distinction that is worth mentioning is that IGF-1, regardless of the variant or type in question, always works systemically in the body. This means that once administered, it circulates throughout the body and works in all muscle tissue and does not contribute to localized muscle growth where it was initially administered.
IGF-1 side effects
The side effect profile of IGF-1 and the most tolerance for most users is generally well accepted based on studies and medical literature, as well as the feedback from bodybuilders and athletes who have used it. However, like everything else, IGF-1 is not without its potential risks and side effects. The majority of IGF-1 side effects manifest themselves more in the form of side effects and risks in the long term, which usually result from long-term use (and of course dosage).
In the short term, this can show the side effect of hypoglycaemia (low blood glucose levels) simply because it is, as mentioned in this article, a nutrient shuttling / partitioning hormone. Because IGF-1 increases the uptake of glucose in muscle cells (and also in other cell types) at a high rate, the risk of rapidly decreasing circulating blood plasma levels of glucose is maintained.
Although this happens at rates that are much lower than those of insulin, it is still a potential risk and a side effect. People who want to use IGF-1 and who are diabetic or diabetic sensitive should be careful with this IGF-1 side effect. Regardless of the potential for diabetes or not, those who want to use IGF-1 should check their blood sugar levels and signs and symptoms of hypoglycaemia and adjust their diet accordingly.
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Because it is indeed a growth factor and a growth hormone in itself, it can promote the growth of tumors and cancer in those individuals who have already been diagnosed with active tumors and / or cancer, as well as those who may have had a history of cancer.
It is important to understand here that IGF-1 does not cause cancer. It is a very important hormone that plays an important role in the proper functioning of our heart, nervous system and brain function in many other functions. With that being said, those who have a history of cancer or who are diagnosed with active cancer patients.
Acromegaly and internal organ and intestinal tissue growth is also a much-discussed IGF-1 side effect. This usually comes with prolonged excessive use, as well as unnecessarily high doses. Acromegaly is the excessive growth of bone tissue, usually manifests noticeably in the jaw, and limbs such as the feet and hands.
As time progresses on the hormone and / or as dosages increase, IGF-1 receptor sites on muscle tissue become saturated, leaving excess IGF-1 in the bloodstream to bind to other tissues (bone, internal organs, and intestinal tissue) and initiate tissue growth in those tissues. Over time one can see why and how this can become a problem (often irreversible) with high doses and longer periods of use.
Dosage, administration and use of IGF-1
Dosages are as follows for IGF-1 LR3: no more than about 40-50mcg per day should be used by men and no more than 20mcg per day for women. Due to the long active half-life in the body, the LR3 variant may only be administered once and no more than twice a day.
On training / training days, the dosage should be administered just before training or just after training. It is preferred by the user, because both before and after is perfectly fine (such as only pre-workout or only after training). If it is administered twice a day, the full daily dose can be divided in two (eg 20mcg before training and 20mcg after training for a total of 40mcg per day). On non-training days, it can be administered at any time of the day.
Dosages are as follows for IGF-1 DES: there is a bit more variation when it comes to the dosage of the DES variant compared to LR3. For IGF-1 DES, the dosage range is more than 50 – 150mcg per day. Due to the much shorter half-life than the LR3 variant, higher dosages can be used without major risks for long-term effects on the body, although caution still needs to be used. It can be used in the same way before / after training as IGF-1 LR3 and is in fact often used in this way due to the short half-life.
IGF-1 LR3 1mg injectable
Any form of IGF-1 can be administered intramuscularly or subcutaneously. The use of both forms should not exceed the total length of 30 days before a minimum of 2 weeks has elapsed, although pauses longer than 2 weeks between IGF-1 cycles are recommended. This is not only because of the risk of long-term health effects, but also to ensure that IGF-1 receptors function properly again after a cycle.
Most IGF-1 preparations (both LR3 and DES variants) usually come as a standard 1 mg total of lyophilized powder. For example, if 2 ml of bacteriostatic water is added to the powder, this will provide the user with 50 mcg per 10 µl (or 0.10 ml) of water. Concentrations can and will vary depending on the product purchased and how the user wants to reconstitute the product with any desired amount of water.
IGF-1 and the law
The laws and legality around IGF-1 can vary widely around the world, and it is up to each individual to carry out his due diligence in investigating and learning the laws of the country, state and / or province in which they stay. many differences between countries, and it is important to know your laws and your rights as an individual. Ignorance is no excuse for breaking the law.
With that being said, most of the Western world (the United States, Canada and the United Kingdom, etc.) do not criminalize the use or possession of IGF-1. In these countries, IGF-1 is not a controlled substance, but its status is that of a prescription-only prescription (for the few IGF-1 preparations that are considered to be used as human medicines) and it cannot be purchased without a prescription as a medicine or supplement for human use.
IGF-1 in one of its variants (LR3 and DES) is very widely available, although very few to no human-grade preparations exist for use as medication. This is largely due to the fact that IGF-1 is still an experimental drug in clinical trials and has not yet been considered an official drug for the treatment of ailments. It is currently being used clinically as an experimental substance and this may change in the future.
For the time being, the availability of IGF-1 is in the form of research peptides sold by various chemical research plants. They can be legally purchased from any number of research companies and / or from their websites.
These are products intended for laboratory research and use only, and unless used in a research and clinical environment approved and sanctioned by the FDA and medical institutions / organizations, they are not intended for human use or consumption. They are not pharmaceutical grade products, nor are they a medical product and are not intended for human use. As such, production standards and quality control will follow.
How can you buy IGF-1?
As mentioned earlier, IGF-1 can be purchased worldwide from research supply suppliers and they are usually accessible through e-commerce purchases via the website. Again, these are products that are intended solely for research and are not manufactured for or intended for human use.
Prices of these products are available for everyone to see openly as advertised on these corporate websites, and both IGF-1 LR3 and DES normally sell in the range of $ 90 – $ 120 per 1 mg lyophilized powder.
The prices depend on the manufacturer and the research agency that sells the product. Other sources are typical anabolic steroid suppliers and sources, both online and offline (personal sources) that also offer IGF-1 products. Again, prices can vary greatly in these cases, but prices normally remain within the aforementioned range.