IGF-1 and its functions in your body

Read about IGF-1 and its functions in your body

IGF-1 Introduction, history and overview

IGF-1, also known as Somatomedin C, has rapidly become a very popular and much-discussed substance in the mid-2000s to the current year 2017. Rumors have it that its first official use as a performance-enhancing drug was in the early 1990s by that time, Mr. Olympia Dorian Yates, which at the time was considered an extremely rare and expensive medicine, after which the use spread rapidly among other professional bodybuilders.

IGF-1 is none anabolic steroid, but is rather a protein hormone (also known as a polypeptide – or simply a peptide hormone) that is extremely similar to the structure of the insulin hormone – another peptide / protein hormone. IGF-1 is endogenous, naturally produced and is synthesized by the human body primarily in the liver. The production of IGF-1 by the liver is stimulated and activated by Human Growth Hormone (HGH). In essence, HGH is a prohormone for IGF-1, and the majority of the anabolic effects of HGH are actually the result of its downstream production.

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IGF-1 LR3 1 mg

Although this peptide is very similar to insulin (hence the name Insulin-like growth factor 1), its role is somewhat different. Like insulin, IGF-1 is a nutrient shuttling hormone that facilitates the transport of nutrients (such as amino acids and glucose) to muscle cells.

The cells themselves can then use those nutrients to synthesize new muscle tissue. IGF-1 is also anabolic in bone tissue, connective tissue and intestinal tissue. This is different from insulin, which is one IGF-1nutrient shuttling hormone is in a broader sense of the word because insulin not only transports nutrients to muscle tissue, but also many other tissues throughout the body. In other words, insulin is not as selective as shuttling hormone as IGF-1 is.

Moreover, IGF-1 plays a very unique and very specific number of roles in the human body and its role changes during human development phases. For example, it is responsible for several important factors involved in growth during childhood and also gives anabolic effects in adults.

Medically, its use is primarily for the treatment of growth disorders, but because IGF-1 is a fairly recent discovery in medicine, its experimental use for the treatment of other conditions continues to widen. Medical use and clinical research extends to conditions such as: dwarfism, aging, neuropathy, cancer and even a stroke.

Different variants of IGF-1 for exogenous administration in the body have been developed for use as late: IGF-1, IGF-1 LR3 and IGF-1 DES, and all have their different properties with regard to half-life and use. These can be confusing for potential users initially, especially with the huge amount of confusing information circulating on the internet, but this will be explained further later in this article.

IGF-1 Chemical properties and properties

IGF-1 is a polypeptide hormone that consists of a chain of 70 amino acids in length. For comparison, insulin consists of 51 amino acids in length. As mentioned earlier, it is a nutrient shuttling hormone that is fairly specific to muscle tissue, and it is an extremely anabolic hormone. It is also anabolic for bone tissue, connective tissue and intestinal tissue.

The fact is that – as mentioned earlier – natural and endogenous IGF-1 production is stimulated by HGH, making HGH essentially a release factor for IGF-1, hence the increased HGH dosing effects are limited by the amount of IGF-1 liver can produce at any time. This is where the benefits of exogenous IGF-1 use come into play. IGF-1, except that it is a nutrient shuttling hormone,

However, a number of very important differences regarding the activity of IGF-1 must be understood: the first is that studies have shown that 99% of IGF-1 circulating in the bloodstream is bound to a number of specific binding proteins, and free (or, unbound) IGF-1 is what is responsible for the proliferation of muscle cells (hyperplasia).

As a result, pharmaceutical research has discovered various methods for modifying the IGF-1 structure to circumvent or avoid this problem of IGF-1 molecules that are bound by binding proteins. The results are, of course, the different variants of IGF-1 that have been developed for use.

The second distinction that is worth mentioning is that IGF-1, regardless of the variant or type in question, always works systemically in the body. This means that once administered, it circulates throughout the body and works in all muscle tissue and does not contribute to localized muscle growth where it was initially administered.

Variants of IGF-1 (IGF-1 LR3, IGF-1 DES)
As mentioned above, IGF-1 is available in mainly 2 different formats / variants. It is important to remember that regardless of the variant, they all work systemically in the body and that despite administration of the hormone intramuscularly directly into a specific muscle, it will not generate measurable localized growth that is worthy of administering in that way. serve.
IGF-1 LR3
This is mentioned first because it is the most common and very popular variant of IGF-1 on the market and is now used by bodybuilders and athletes. It contains bioidentical IGF-1 consisting of the original 70 amino acid chain, but with an additional 13 amino acids at its N-terminus for a total of 83 amino acids. It also has a second modification in which an arginine is located at the 3rd position instead of the original glutamic acid. The result of these modifications is that the IGF-1 still exhibits its original activity on the IGF-1 receptor in body tissues and has a very low binding affinity for the aforementioned IGF binding proteins. It also exhibits a significantly extended half-life of about 20 – 30 hours as opposed to the 12-hour half-life of IGF-1. All of these combined factors have shown that LR3 is approximately three times the potency of IGF-1.

IGF-1 DES
Also known as DES (1-3) IGF-1, this is what is commonly known as the very fast acting form of IGF-1 and is usually the less preferred of the two. The modifications of the original IGF-1 molecule are such that it lacks the first 3 amino acids at the N-terminus, giving IGF-1 DES a total of 67 amino acids in its chain compared to the original 70. This modification confers IGF-1 DES with a reduced binding affinity for the IGF-binding proteins mentioned earlier, together with increased strength and potency approximately ten times that of the original IGF-1 and five times that of IGF-1 LR3. Unlike IGF-1 LR3, IGF-1 DES has a much shorter half-life of approximately 20 – 30 minutes. Due to its faster activity and greater strength / potency, the DES variant of IGF-1 is often believed to achieve localized muscle growth at the site where it is injected. Although there is some truth, studies have shown that, like IGF-1 in general, it will work systemically once it reaches capillaries and blood flow.
IGF-1 side effects

The side effect profile of IGF-1 and the most tolerance for most users is generally well accepted based on studies and medical literature, as well as the feedback from bodybuilders and athletes who have used it. However, like everything else, IGF-1 is not without its potential risks and side effects. The majority of IGF-1 side effects manifest themselves more in the form of side effects and risks in the long term, which usually result from long-term use (and IGF-1 is a polypeptide hormoneof course dosage).

In the short term, this can show the side effect of hypoglycaemia (low blood glucose levels) simply because it is, as mentioned in this article, a nutrient shuttling / partitioning hormone. Because IGF-1 increases the uptake of glucose in muscle cells (and also in other cell types) at a high rate, the risk of rapidly decreasing circulating blood plasma levels of glucose is maintained.

Although this happens at rates that are much lower than those of insulin, it is still a potential risk and a side effect. People who want to use IGF-1 and who are diabetic or diabetic sensitive should be careful with this IGF-1 side effect. Regardless of the potential for diabetes or not, those who want to use IGF-1 should check their blood sugar levels and signs and symptoms of hypoglycaemia and adjust their diet accordingly.

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Serious implications

Because it is indeed a growth factor and a growth hormone in itself, it can promote the growth of tumors and cancer in those individuals who have already been diagnosed with active tumors and / or cancer, as well as those who may have had a history of cancer.

It is important to understand here that IGF-1 does not cause cancer. It is a very important hormone that plays an important role in the proper functioning of our heart, nervous system and brain function in many other functions. With that being said, those who have a history of cancer or who are diagnosed with active cancer patients.

Acromegaly and internal organ and intestinal tissue growth is also a much-discussed IGF-1 side effect. This usually comes with prolonged excessive use, as well as unnecessarily high doses. Acromegaly is the excessive growth of bone tissue, usually manifests noticeably in the jaw, and limbs such as the feet and hands.

For this to happen, periods of long-term uninterrupted use and high doses are required. It is advised not to use an IGF-1 cycle (especially IGF-1 LR3) for more than 30 consecutive days before a significant interruption of the connection occurs.

As time progresses on the hormone and / or as dosages increase, IGF-1 receptor sites on muscle tissue become saturated, leaving excess IGF-1 in the bloodstream to bind to other tissues (bone, internal organs, and intestinal tissue) and initiate tissue growth in those tissues. Over time one can see why and how this can become a problem (often irreversible) with high doses and longer periods of use.

Dosage, administration and use of IGF-1

Dosages are as follows for IGF-1 LR3: no more than about 40-50mcg per day should be used by men and no more than 20mcg per day for women. Due to the long active half-life in the body, the LR3 variant may only be administered once and no more than twice a day.

use of IGF-1On training / training days, the dosage should be administered just before training or just after training. It is preferred by the user, because both before and after is perfectly fine (such as only pre-workout or only after training). If it is administered twice a day, the full daily dose can be divided in two (eg 20mcg before training and 20mcg after training for a total of 40mcg per day). On non-training days, it can be administered at any time of the day.

Dosages are as follows for IGF-1 DES: there is a bit more variation when it comes to the dosage of the DES variant compared to LR3. For IGF-1 DES, the dosage range is more than 50 – 150mcg per day. Due to the much shorter half-life than the LR3 variant, higher dosages can be used without major risks for long-term effects on the body, although caution still needs to be used. It can be used in the same way before / after training as IGF-1 LR3 and is in fact often used in this way due to the short half-life.

IGF-1 LR3 1mg injectable

Any form of IGF-1 can be administered intramuscularly or subcutaneously. The use of both forms should not exceed the total length of 30 days before a minimum of 2 weeks has elapsed, although pauses longer than 2 weeks between IGF-1 cycles are recommended. This is not only because of the risk of long-term health effects, but also to ensure that IGF-1 receptors function properly again after a cycle.

Both variants will be packaged in a lyophilized powder format (a dehydrated / dehydrated powder) to be reconstituted, either with bacteriostatic water, or – usually in the case of LR3 – a small amount of acetic acid diluted in bacteriostatic water. It is the responsibility of the user to calculate how much water he or she must add to the lyophilized powder to properly reconstitute it to form a desired concentration.

Most IGF-1 preparations (both LR3 and DES variants) usually come as a standard 1 mg total of lyophilized powder. For example, if 2 ml of bacteriostatic water is added to the powder, this will provide the user with 50 mcg per 10 µl (or 0.10 ml) of water. Concentrations can and will vary depending on the product purchased and how the user wants to reconstitute the product with any desired amount of water.

IGF-1 and the law

The laws and legality around IGF-1 can vary widely around the world, and it is up to each individual to carry out his due diligence in investigating and learning the laws of the country, state and / or province in which they stay. many differences between countries, and it is important to know your laws and your rights as an individual. Ignorance is no excuse for breaking the law.

With that being said, most of the Western world (the United States, Canada and the United Kingdom, etc.) do not criminalize the use or possession of IGF-1. In these countries, IGF-1 is not a controlled substance, but its status is that of a prescription-only prescription (for the few IGF-1 preparations that are considered to be used as human medicines) and it cannot be purchased without a prescription as a medicine or supplement for human use.

IGF-1 availability

IGF-1 in one of its variants (LR3 and DES) is very widely available, although very few to no human-grade preparations exist for use as medication. This is largely due to the fact that IGF-1 is still an experimental drug in clinical trials and has not yet been considered an official drug for the treatment of ailments. It is currently being used clinically as an experimental substance and this may change in the future.

For the time being, the availability of IGF-1 is in the form of research peptides sold by various chemical research plants. They can be legally purchased from any number of research companies and / or from their websites.

These are products intended for laboratory research and use only, and unless used in a research and clinical environment approved and sanctioned by the FDA and medical institutions / organizations, they are not intended for human use or consumption. They are not pharmaceutical grade products, nor are they a medical product and are not intended for human use. As such, production standards and quality control will follow.

Some products of the underground laboratory (UGL) of this compound do exist, but they are far and few in between, and should be viewed with research in view of the easy access to legal research-only products of this compound in the open market.

How can you buy IGF-1?

As mentioned earlier, IGF-1 can be purchased worldwide from research supply suppliers and they are usually accessible through e-commerce purchases via the website. Again, these are products that are intended solely for research and are not manufactured for or intended for human use.

Prices of these products are available for everyone to see openly as advertised on these corporate websites, and both IGF-1 LR3 and DES normally sell in the range of $ 90 – $ 120 per 1 mg lyophilized powder.

The prices depend on the manufacturer and the research agency that sells the product. Other sources are typical anabolic steroid suppliers and sources, both online and offline (personal sources) that also offer IGF-1 products. Again, prices can vary greatly in these cases, but prices normally remain within the aforementioned range.